Karyotype evolution and acquisition of FLT3 or RAS pathway alterations drive progression of myelodysplastic syndrome to acute myeloid leukemia

Haematologica. 2015 Dec;100(12):e487-90. doi: 10.3324/haematol.2015.127985. Epub 2015 Aug 20.
No abstract available

Keywords: MDS; mutation analysis; s-AML.

Publication types

  • Letter

MeSH terms

  • Abnormal Karyotype*
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / pathology
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes / genetics*
  • Myelodysplastic Syndromes / pathology
  • fms-Like Tyrosine Kinase 3 / genetics*
  • ras Proteins / genetics*

Substances

  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3
  • ras Proteins