Management of cutaneous squamous cell carcinoma in patients with epidermolysis bullosa: best clinical practice guidelines

J E Mellerio; S J Robertson; C Bernardis; A Diem; J D Fine; R George; D Goldberg; G B Halmos; M Harries; M F Jonkman; A Lucky; A E Martinez; E Maubec; S Morris; D F Murrell; F Palisson; E I Pillay; A Robson; J C Salas-Alanis; J A McGrath

doi:10.1111/bjd.14104

Management of cutaneous squamous cell carcinoma in patients with epidermolysis bullosa: best clinical practice guidelines

Br J Dermatol. 2016 Jan;174(1):56-67. doi: 10.1111/bjd.14104. Epub 2015 Nov 7.

Authors

J E Mellerio^{1

2}, S J Robertson³, C Bernardis⁴, A Diem⁵, J D Fine⁶, R George⁷, D Goldberg⁸, G B Halmos⁹, M Harries¹⁰, M F Jonkman¹¹, A Lucky¹², A E Martinez², E Maubec¹³, S Morris¹⁰, D F Murrell¹⁴, F Palisson¹⁵, E I Pillay¹, A Robson¹⁶, J C Salas-Alanis¹⁷, J A McGrath¹⁸

Affiliations

¹ St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, U.K.
² Department of Dermatology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, U.K.
³ Department of Dermatology, The Royal Melbourne Hospital, The Royal Children's Hospital and Monash Medical Centre, Melbourne, Australia.
⁴ Department of Plastic Surgery, Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, U.K.
⁵ Department of Dermatology, Paracelsus Medical University, Salzburg, Austria.
⁶ Division of Dermatology, Vanderbilt University School of Medicine, Nashville, TN, U.S.A.
⁷ Department of Palliative Care, Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, U.K.
⁸ Division of Dermatology, University of Massachusetts, Worcester, MA, U.S.A.
⁹ Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre Groningen, Groningen, the Netherlands.
¹⁰ Department of Oncology, Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, U.K.
¹¹ Department of Dermatology, University Medical Centre Groningen, Groningen, the Netherlands.
¹² Department of Dermatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, U.S.A.
¹³ Department of Dermatology, APHP, Avicenne Hospital, Bobigny, France.
¹⁴ Department of Dermatology, St George Hospital, University of New South Wales, Sydney, Australia.
¹⁵ Facultad de Medicina, Clínica Alemana, Santiago, Chile.
¹⁶ Department of Dermatopathology, Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, U.K.
¹⁷ Basic Sciences Department, Universidad de Monterrey, Monterrey, Mexico.
¹⁸ St John's Institute of Dermatology, King's College London (Guy's Campus), London, U.K.

PMID: 26302137
DOI: 10.1111/bjd.14104

Abstract

This article summarizes recommendations reached following a systematic literature review and expert consensus on the diagnosis and management of cutaneous squamous cell carcinomas in people with epidermolysis bullosa. The guidelines are intended to help inform decision making by clinicians dealing with this complex complication of a devastating disease.

Publication types

Review
Systematic Review

MeSH terms

Amputation, Surgical / methods
Artificial Limbs
Carcinoma, Squamous Cell / diagnosis
Carcinoma, Squamous Cell / prevention & control
Carcinoma, Squamous Cell / therapy*
Consensus
Epidermolysis Bullosa / complications*
Humans
Lymphatic Metastasis
Minimally Invasive Surgical Procedures / methods
Neoplasm Metastasis
Neoplasm Staging
Pain / prevention & control
Practice Guidelines as Topic
Psychotherapy / methods
Retinoids / therapeutic use
Sentinel Lymph Node Biopsy / methods
Skin Neoplasms / diagnosis
Skin Neoplasms / prevention & control
Skin Neoplasms / therapy*
Terminal Care / methods
Wound Closure Techniques

Substances

Retinoids