Determination of a novel dipeptidyl peptidase IV inhibitor in monkey plasma by HPLC-MS/MS and its application in a pharmacokinetics study

J Pharm Biomed Anal. 2016 Jan 5:117:99-103. doi: 10.1016/j.jpba.2015.08.033. Epub 2015 Aug 29.

Abstract

A lot of attention has been given to novel diabetes treatment, which is used to replace injectable insulin. A novel dipeptidyl peptidase IV inhibitor (HWH-10d) for treating type 2 diabetes was previously determined to have comparable efficacy to the marketed drug (alogliptin) in ICR male mice. Therefore, a sensitive and rapid liquid chromatography-tandem mass spectrometric method was developed and validated for the further evaluation of HWH-10d in monkey. The analytes were extracted through a liquid-liquid extraction with ethyl acetate. The linear detection range for HWH-10d in monkey plasma was from 0.5 to 2000 ng/mL with the lower limit of quantification of 0.5 ng/mL. The relative standard deviation was measured to be less than 10.4% for determination of inter- and intra-day precisions, and the relative error was determined to be within ±7.2% for all accuracy measurements. The simple and rapid LC-MS/MS method for HWH-10d in monkey plasma could be used for the pharmacokinetics studies of HWH-10d in monkeys. The oral bioavailability of HWH-10d in monkeys is 57.8%.

Keywords: DPP-IV inhibitor; HWH-10d; LC–MS/MS; Pharmacokinetics; Type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid / methods
  • Dipeptidyl-Peptidase IV Inhibitors / blood*
  • Dipeptidyl-Peptidase IV Inhibitors / pharmacokinetics*
  • Female
  • Macaca fascicularis
  • Male
  • Tandem Mass Spectrometry / methods*

Substances

  • Dipeptidyl-Peptidase IV Inhibitors