Lactic acidosis: Clinical implications and management strategies

Anita J Reddy; Simon W Lam; Seth R Bauer; Jorge A Guzman

doi:10.3949/ccjm.82a.14098

Lactic acidosis: Clinical implications and management strategies

Cleve Clin J Med. 2015 Sep;82(9):615-24. doi: 10.3949/ccjm.82a.14098.

Authors

Anita J Reddy^{1

2}, Simon W Lam^{3

2}, Seth R Bauer⁴, Jorge A Guzman⁵

Affiliations

¹ Quality Officer, Medical Intensive Care Unit, Departments of Pulmonary Medicine and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA. E-mail: reddya3@ccf.org.
² Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
³ Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
⁴ Medical ICU Clinical Specialist, Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
⁵ Director, Medical Intensive Care Unit, Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.

PMID: 26366959
DOI: 10.3949/ccjm.82a.14098

Abstract

In hospitalized patients, elevated serum lactate levels are both a marker of risk and a target of therapy. The authors describe the mechanisms underlying lactate elevations, note the risks associated with lactic acidosis, and outline a strategy for its treatment.

Publication types

Review

MeSH terms

Acidosis, Lactic* / blood
Acidosis, Lactic* / diagnosis
Acidosis, Lactic* / etiology
Acidosis, Lactic* / physiopathology
Acidosis, Lactic* / therapy
Cardiotonic Agents / therapeutic use*
Disease Management
Fluid Therapy / methods*
Humans
Oxygen Inhalation Therapy / methods*
Shock, Septic / complications*
Vasoconstrictor Agents / therapeutic use*

Substances

Cardiotonic Agents
Vasoconstrictor Agents