Comprehensive quantitative proteomic profiling of the pharmacodynamic changes induced by MLN4924 in acute myeloid leukemia cells establishes rationale for its combination with azacitidine

Leukemia. 2016 May;30(5):1190-4. doi: 10.1038/leu.2015.250. Epub 2015 Sep 15.
No abstract available

Publication types

  • Letter

MeSH terms

  • Azacitidine / administration & dosage*
  • Cell Line, Tumor
  • Cyclopentanes / administration & dosage
  • Cyclopentanes / pharmacology*
  • Humans
  • Leukemia, Myeloid, Acute / metabolism*
  • Leukemia, Myeloid, Acute / pathology
  • Neoplasm Proteins / metabolism*
  • Proteomics*
  • Pyrimidines / administration & dosage
  • Pyrimidines / pharmacology*

Substances

  • Cyclopentanes
  • Neoplasm Proteins
  • Pyrimidines
  • Azacitidine
  • pevonedistat