Quantitative structure activity relationships of 2-amino-3-carboxylic acid ethyl ester thiophene derivatives are described. These compounds exhibit a weak anti-edema activity and a more significant analgesic activity relative to acetylsalicylic acid and oxyphenylbutazone. The application of statistical analysis has shown that for analgesic activity, lipophilic parameters and molar refractivity seem to be the parameters giving the best explanations of variances of biological data for eight compounds, the lipophilicity exhibits a degree of correlation of 81.9% regarding anti-inflammatory activity.