Diagnostic Accuracy of Seven Commercial Assays for Rapid Detection of Group A Rotavirus Antigens

J Clin Microbiol. 2015 Nov;53(11):3670-3. doi: 10.1128/JCM.01984-15. Epub 2015 Sep 16.

Abstract

Seven commercial immunochromatographic assays intended for the detection of group A rotavirus antigens in human stool samples were evaluated. These assays showed similar levels of diagnostic accuracy and were suitable for the detection of rotavirus in patients with acute gastroenteritis but missed some asymptomatic rotavirus shedding identified by real-time reverse transcription-PCR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antigens, Viral / immunology*
  • Child
  • Child, Preschool
  • Chromatography, Affinity / methods*
  • False Negative Reactions
  • Feces / virology
  • Female
  • Gastroenteritis / diagnosis*
  • Gastroenteritis / virology
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Reagent Kits, Diagnostic
  • Real-Time Polymerase Chain Reaction / methods
  • Rotavirus / classification*
  • Rotavirus / immunology
  • Rotavirus Infections / diagnosis*
  • Rotavirus Infections / virology
  • Sensitivity and Specificity
  • Young Adult

Substances

  • Antigens, Viral
  • Reagent Kits, Diagnostic