Successful Treatment of Carbapenemase-Producing Pandrug-Resistant Klebsiella pneumoniae Bacteremia

Jose F Camargo; Jacques Simkins; Thiago Beduschi; Akin Tekin; Laura Aragon; Armando Pérez-Cardona; Clara E Prado; Michele I Morris; Lilian M Abbo; Rafael Cantón

doi:10.1128/AAC.00655-15

Successful Treatment of Carbapenemase-Producing Pandrug-Resistant Klebsiella pneumoniae Bacteremia

Antimicrob Agents Chemother. 2015 Oct;59(10):5903-8. doi: 10.1128/AAC.00655-15.

Authors

Affiliations

¹ Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA jfc31@med.miami.edu rafael.canton@salud.madrid.org.
² Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
³ Miami Transplant Institute and Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
⁴ Department of Pharmacy, Jackson Memorial Hospital, Miami, Florida, USA.
⁵ Department of Microbiology, Jackson Memorial Hospital, Miami, Florida, USA.
⁶ Department of Microbiology, University of Miami, Miami, Florida, USA.
⁷ Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain jfc31@med.miami.edu rafael.canton@salud.madrid.org.

Abstract

New antibiotic options are urgently needed for the treatment of carbapenem-resistant Enterobacteriaceae infections. We report a 64-year-old female with prolonged hospitalization following an intestinal transplant who developed refractory bacteremia due to a serine carbapenemase-producing pandrug-resistant isolate of Klebsiella pneumoniae. After failing multiple antimicrobial regimens, the patient was successfully treated.

Publication types

Case Reports

MeSH terms

Anti-Bacterial Agents / therapeutic use*
Antiviral Agents / therapeutic use
Azabicyclo Compounds / therapeutic use
Bacteremia / drug therapy*
Bacteremia / microbiology
Bacteremia / pathology
Bacterial Proteins / biosynthesis*
Carbapenems / therapeutic use
Ceftazidime / therapeutic use
Colectomy
Colistin / therapeutic use
Drug Combinations
Drug Resistance, Multiple, Bacterial
Female
Ganciclovir / analogs & derivatives
Ganciclovir / therapeutic use
Humans
Immunosuppressive Agents / therapeutic use
Intestine, Small / drug effects*
Intestine, Small / microbiology
Intestine, Small / transplantation
Klebsiella Infections / drug therapy*
Klebsiella Infections / microbiology
Klebsiella Infections / pathology
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / enzymology
Klebsiella pneumoniae / growth & development
Meropenem
Microbial Sensitivity Tests
Middle Aged
Minocycline / analogs & derivatives
Minocycline / therapeutic use
Thienamycins / therapeutic use
Tigecycline
Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
Valganciclovir
beta-Lactamases / biosynthesis*

Substances

Anti-Bacterial Agents
Antiviral Agents
Azabicyclo Compounds
Bacterial Proteins
Carbapenems
Drug Combinations
Immunosuppressive Agents
Thienamycins
avibactam, ceftazidime drug combination
Tigecycline
Trimethoprim, Sulfamethoxazole Drug Combination
Ceftazidime
beta-Lactamases
carbapenemase
Meropenem
Minocycline
Valganciclovir
Ganciclovir
Colistin