How Do RIM-BPs Link Voltage-Gated Ca(2+) Channels to Evoked Neurotransmitter Release?

Neuron. 2015 Sep 23;87(6):1119-1121. doi: 10.1016/j.neuron.2015.09.005.

Abstract

Coupling between voltage-gated Ca(2+) influx and synaptic vesicle exocytosis is essential for rapid evoked neurotransmission. Acuna et al. show that the knockout of RIM-BPs, which are key structural components of this coupling, decreases the reliability of evoked neurotransmitter release.

Publication types

  • Comment

MeSH terms

  • ATP-Binding Cassette Transporters / physiology*
  • Action Potentials / physiology*
  • Animals
  • Calcium / metabolism*
  • Humans
  • Neurotransmitter Agents / metabolism*
  • rab3 GTP-Binding Proteins / physiology*

Substances

  • ATP-Binding Cassette Transporters
  • Neurotransmitter Agents
  • rab3 GTP-Binding Proteins
  • Calcium