Innate immune cells in the pathogenesis of primary systemic vasculitis

Rheumatol Int. 2016 Feb;36(2):169-82. doi: 10.1007/s00296-015-3367-1. Epub 2015 Sep 24.

Abstract

Innate immune system forms the first line of defense against foreign substances. Neutrophils, eosinophils, erythrocytes, platelets, monocytes, macrophages, dendritic cells, γδ T cells, natural killer and natural killer T cells comprise the innate immune system. Genetic polymorphisms influencing the activation of innate immune cells predispose to development of vasculitis and influence its severity. Abnormally activated innate immune cells cross-talk with other cells of the innate immune system, present antigens more efficiently and activate T and B lymphocytes and cause tissue destruction via cell-mediated cytotoxicity and release of pro-inflammatory cytokines. These secreted cytokines further recruit other cells to the sites of vascular injury. They are involved in both the initiation as well as the perpetuation of vasculitis. Evidences suggest reversal of aberrant activation of immune cells in response to therapy. Understanding the role of innate immune cells in vasculitis helps understand the potential of therapeutic modulation of their activation to treat vasculitis.

Keywords: Innate immunity; Monocytes; Myeloid cells; Pathogenesis; Platelets; Vasculitis.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Platelets / immunology*
  • Blood Platelets / pathology
  • Cell Communication
  • Humans
  • Immune System / immunology*
  • Immune System / pathology
  • Immune System / physiopathology
  • Immunity, Innate*
  • Inflammation Mediators / immunology
  • Monocytes / immunology*
  • Monocytes / pathology
  • Myeloid Cells / immunology*
  • Myeloid Cells / pathology
  • Phenotype
  • Signal Transduction
  • Systemic Vasculitis / immunology*
  • Systemic Vasculitis / pathology
  • Systemic Vasculitis / physiopathology

Substances

  • Inflammation Mediators