Clinical Outcome Measures in Chiari I Malformation

Chester K Yarbrough; Jacob K Greenberg; Tae Sung Park

doi:10.1016/j.nec.2015.06.008

Clinical Outcome Measures in Chiari I Malformation

Neurosurg Clin N Am. 2015 Oct;26(4):533-41. doi: 10.1016/j.nec.2015.06.008. Epub 2015 Aug 4.

Authors

Chester K Yarbrough¹, Jacob K Greenberg², Tae Sung Park³

Affiliations

¹ Department of Neurological Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8057, St. Louis, MO 63110, USA. Electronic address: yarbroughc@wustl.edu.
² Department of Neurological Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8057, St. Louis, MO 63110, USA.
³ Department of Neurological Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8057, St. Louis, MO 63110, USA; Department of Neurological Surgery, St Louis Children's Hospital, Suite 4S20, St Louis, MO 63110, USA.

PMID: 26408063
DOI: 10.1016/j.nec.2015.06.008

Abstract

Chiari malformation type 1 (CM-I) is a common and often debilitating neurologic disease. Reliable evaluation of treatments has been hampered by inconsistent use of clinical outcome measures. A variety of outcome measurement tools are available, although few have been validated in CM-I. The recent development of the Chicago Chiari Outcome Scale and the Chiari Symptom Profile provides CM-I-specific instruments to measure outcomes in adults and children, although validation and refinement may be necessary.

Keywords: Chiari malformation type 1; Clinical research; Outcome instruments; Outcome methods; Quality of life; Treatment outcome.

Publication types

Review

MeSH terms

Arnold-Chiari Malformation / diagnosis
Arnold-Chiari Malformation / therapy*
Humans
Observer Variation*
Outcome Assessment, Health Care*
Postoperative Complications / diagnosis*
Postoperative Complications / therapy
Predictive Value of Tests*
Reproducibility of Results