[Management of myelodysplastic syndromes]

Bull Cancer. 2015 Nov;102(11):946-57. doi: 10.1016/j.bulcan.2015.07.007. Epub 2015 Sep 26.
[Article in French]

Abstract

Myelodysplastic syndromes are heterogeneous diseases whose molecular characteristics have only been identified in recent years. Better identification of prognostic factors, larger access to allogeneic stem cell transplantation and the advent of new drugs notably hypomethylating agents (azacitidine, decitabine) and lenalidomide have improved patient outcome.

Keywords: Caractérisation; Characterization; Cytogenetic; Cytogénétique; Molecular; Moléculaire; Myelodysplastic syndrome; Syndromes myélodysplasiques; Traitement; Treatment.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Aged
  • Anemia / therapy
  • Antineoplastic Agents / adverse effects
  • Cellular Microenvironment
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Myelodysplastic Syndromes / diagnosis
  • Myelodysplastic Syndromes / epidemiology
  • Myelodysplastic Syndromes / etiology
  • Myelodysplastic Syndromes / therapy*
  • Prognosis
  • Radiotherapy / adverse effects
  • Risk Factors
  • Thrombocytopenia / therapy

Substances

  • Antineoplastic Agents