Efficient methods for enol phosphate synthesis using carbon-centred magnesium bases

Org Biomol Chem. 2015 Oct 28;13(40):10131-5. doi: 10.1039/c5ob01849h. Epub 2015 Sep 28.

Abstract

Efficient conversion of ketones into kinetic enol phosphates under mild and accessible conditions has been realised using the developed methods with di-tert-butylmagnesium and bismesitylmagnesium. Optimisation of the quench protocol resulted in high yields of enol phosphates from a range of cyclohexanones and aryl methyl ketones, with tolerance of a range of additional functional units.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon / chemistry*
  • Ketones / chemistry
  • Kinetics
  • Magnesium / chemistry*
  • Molecular Structure
  • Phosphates / chemical synthesis*
  • Phosphates / chemistry

Substances

  • Ketones
  • Phosphates
  • Carbon
  • Magnesium