Benzophenone and its analogs bind to human glyoxalase 1

Doina M Mihai; Steven Hall; Haiteng Deng; Christopher J Welch; Akira Kawamura

doi:10.1016/j.bmcl.2015.09.036

Benzophenone and its analogs bind to human glyoxalase 1

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5349-51. doi: 10.1016/j.bmcl.2015.09.036. Epub 2015 Sep 15.

Authors

Doina M Mihai¹, Steven Hall¹, Haiteng Deng², Christopher J Welch³, Akira Kawamura¹

Affiliations

¹ Department of Chemistry, Hunter College and The CUNY Graduate Center, 695 Park Avenue, New York, NY 10065, USA.
² School of Life Sciences, Tsinghua University, Haidian District, Beijing 100084, China.
³ Department of Process & Analytical Chemistry, Merck & Co., Inc., Rahway, NJ 07065, USA.

Abstract

Benzophenone is a popular photophore for photoaffinity-labeling. It is also an important framework for drug development; many drugs contain benzophenone or analogous frameworks. The current work reports that benzophenone and its analogs bind to human glyoxalase 1. The binding, however, has little effect on the catalytic activity of this enzyme. The implications of the finding in terms of both drug development and photoaffinity-labeling are discussed.

Keywords: Doxorubicin; Fenofibrate; GLO1; Ketoprofen; Off-target; Photoaffinity-labeling.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Benzophenones / chemistry*
Benzophenones / metabolism
Humans
Lactoylglutathione Lyase / metabolism*
Molecular Structure
Protein Binding

Substances

Benzophenones
benzophenone
Lactoylglutathione Lyase

Abstract

Publication types

MeSH terms

Substances

Grants and funding