Core-Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra-large Cavity for Protein Delivery

Chun Xu; Meihua Yu; Owen Noonan; Jun Zhang; Hao Song; Hongwei Zhang; Chang Lei; Yuting Niu; Xiaodan Huang; Yannan Yang; Chengzhong Yu

doi:10.1002/smll.201501449

Core-Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra-large Cavity for Protein Delivery

Small. 2015 Nov 25;11(44):5949-55. doi: 10.1002/smll.201501449. Epub 2015 Oct 1.

Authors

Chun Xu¹, Meihua Yu¹, Owen Noonan¹, Jun Zhang¹, Hao Song¹, Hongwei Zhang¹, Chang Lei¹, Yuting Niu¹, Xiaodan Huang¹, Yannan Yang¹, Chengzhong Yu¹

Affiliation

¹ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.

PMID: 26426420
DOI: 10.1002/smll.201501449

Abstract

A new type of monodispersed mesoporous silica nanoparticles with a core-cone structure (MSN-CC) has been synthesized. The large cone-shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN-CC has a large pore size of 45 nm and a high pore volume of 2.59 cm(3) g(-1). MSN-CC demonstrates a high loading capacity of large proteins and successfully delivers active β-galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights.

Keywords: large pores; mesoporous silica; nanoparticles; protein delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Dahlia / anatomy & histology
Drug Delivery Systems / methods*
Mice
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Porosity
Silicon Dioxide / chemistry*
beta-Galactosidase / metabolism*

Substances

Silicon Dioxide
beta-Galactosidase