Abstract
Our previous studies have demonstrated the critical roles of calcium-stimulated adenylyl cyclase 1 (AC1) in the central nervous system in chronic pain. In the present study, we examined the analgesic effects of NB001, a selective inhibitor of AC1, on animal models of ankle joint arthritis and knee joint arthritis induced by complete Freund's adjuvant injection. NB001 treatment had no effect on joint edema, stiffness, and joint destruction. Furthermore, the treatment failed to attenuate the disease progression of arthritis. However, NB001 treatment (3 mg/kg) significantly weakened joint pain-related behavior in the mouse models of ankle joint arthritis and knee joint arthritis. Results indicated that NB001 exhibited an analgesic effect on the animal models of arthritis but was not caused by anti-inflammatory activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / analogs & derivatives*
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Adenosine Triphosphate / pharmacology
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Adenosine Triphosphate / therapeutic use
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Analgesics / pharmacology
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Analgesics / therapeutic use*
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Animals
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Arthralgia / complications
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Arthralgia / drug therapy*
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Arthralgia / pathology
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Arthralgia / physiopathology
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Behavior, Animal
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Disease Models, Animal
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Freund's Adjuvant
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Hyperalgesia / complications
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Hyperalgesia / drug therapy
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Hyperalgesia / physiopathology
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Inflammation / complications
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Inflammation / drug therapy
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Inflammation / pathology
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Knee Joint / drug effects
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Knee Joint / pathology
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Male
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Mice, Inbred C57BL
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Pain / complications
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Pain / drug therapy
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Pain / pathology
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Sensory Thresholds
Substances
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5-((2-(6-Amino-9H-purin-9-yl) ethyl) amino)-1-pentanol
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Analgesics
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Adenosine Triphosphate
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Freund's Adjuvant