A structural snapshot of the rhodopsin-arrestin complex

FEBS J. 2016 Mar;283(5):816-21. doi: 10.1111/febs.13561. Epub 2015 Nov 7.

Abstract

The crystal structure of the rhodopsin-arrestin complex provides important insights into how G protein-coupled receptor signaling is terminated by arrestin and a structural basis for understanding the mechanism of arrestin-based signaling.

Keywords: G protein; G protein-coupled receptors; Rhodopsin; arrestin; biased signalling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arrestins / chemistry*
  • Crystallization
  • Crystallography, X-Ray
  • Humans
  • Ligands
  • Lipid Bilayers / chemistry
  • Phosphorylation
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Tertiary
  • Receptors, Adrenergic, beta-2 / metabolism*
  • Receptors, G-Protein-Coupled / metabolism*
  • Rhodopsin / chemistry*
  • Signal Transduction

Substances

  • Arrestins
  • Ligands
  • Lipid Bilayers
  • Receptors, Adrenergic, beta-2
  • Receptors, G-Protein-Coupled
  • Rhodopsin