Data in brief: Transcriptome analysis of induced pluripotent stem cells from monozygotic twins discordant for trisomy 21

Youssef Hibaoui; Iwona Grad; Audrey Letourneau; Federico A Santoni; Stylianos E Antonarakis; Anis Feki

doi:10.1016/j.gdata.2014.07.006

Data in brief: Transcriptome analysis of induced pluripotent stem cells from monozygotic twins discordant for trisomy 21

Genom Data. 2014 Aug 1:2:226-9. doi: 10.1016/j.gdata.2014.07.006. eCollection 2014 Dec.

Authors

Youssef Hibaoui¹, Iwona Grad², Audrey Letourneau³, Federico A Santoni³, Stylianos E Antonarakis⁴, Anis Feki⁵

Affiliations

¹ Stem Cell Research Laboratory, Department of Obstetrics and Gynecology, Geneva University Hospitals, 30 bd de la Cluse, CH-1211 Geneva, Switzerland ; Department of Genetic Medicine and Development, University of Geneva Medical School and Geneva University Hospitals, 1 rue Michel-Servet, CH-1211 Geneva, Switzerland.
² Stem Cell Research Laboratory, Department of Obstetrics and Gynecology, Geneva University Hospitals, 30 bd de la Cluse, CH-1211 Geneva, Switzerland.
³ Department of Genetic Medicine and Development, University of Geneva Medical School and Geneva University Hospitals, 1 rue Michel-Servet, CH-1211 Geneva, Switzerland.
⁴ Department of Genetic Medicine and Development, University of Geneva Medical School and Geneva University Hospitals, 1 rue Michel-Servet, CH-1211 Geneva, Switzerland ; iGE3 Institute of Genetics and Genomics of Geneva, University of Geneva, Switzerland.
⁵ Stem Cell Research Laboratory, Department of Obstetrics and Gynecology, Geneva University Hospitals, 30 bd de la Cluse, CH-1211 Geneva, Switzerland ; Department of Obstetrics and Gynecology, HFR Fribourg-Hôpital cantonal, Chemin des Pensionnats 2-6, Case postale 1708 Fribourg, Switzerland.

Abstract

Down syndrome (DS, trisomy 21), is the most common viable chromosomal disorder, with an incidence of 1 in 800 live births. Its phenotypic characteristics include intellectual impairment and several other developmental abnormalities, for the majority of which the pathogenetic mechanisms remain unknown. In this "Data in Brief" paper, we sum up the whole genome analysis by mRNA sequencing of normal and DS induced pluripotent stem cells that was recently published by Hibaoui et al. in EMBO molecular medicine.

Keywords: Chromosome 21; Down syndrome; Induced pluripotent stem cells; mRNA sequencing.

Grants and funding

249968/ERC_/European Research Council/International