Abstract
MicroRNAs (miRNAs) are dysregulated in many types of malignancies, including human hepatocellular carcinoma (HCC). MiR-107 has been implicated in several types of cancer regulation; however, relatively little is known about miR-107 in human HCC. In the present study, we showed that the overexpression of miR-107 accelerates the tumor progression of HCC in vitro and in vivo through its new target gene, CPEB3. Furthermore, our results demonstrated that CPEB3 is a newly discovered tumor suppressor that acts via the EGFR pathway. Therefore, our study demonstrates that the newly discovered miR-107/CPEB3/EGFR axis plays an important role in HCC progression and might represent a new potential therapeutic target for HCC treatment.
Keywords:
CPEB3; EGFR; hepatocellular carcinoma; microRNA; microRNA-107.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
3' Untranslated Regions / genetics
-
Animals
-
Blotting, Western
-
Carcinoma, Hepatocellular / genetics*
-
Carcinoma, Hepatocellular / metabolism
-
Carcinoma, Hepatocellular / pathology
-
Cell Line, Tumor
-
Cell Movement / genetics
-
Cell Proliferation / genetics
-
Disease Progression
-
ErbB Receptors / genetics*
-
ErbB Receptors / metabolism
-
Gene Expression Regulation, Neoplastic
-
Liver Neoplasms / genetics*
-
Liver Neoplasms / metabolism
-
Liver Neoplasms / pathology
-
Male
-
Mice, Inbred BALB C
-
Mice, Nude
-
MicroRNAs / genetics*
-
Neoplasm Metastasis
-
RNA Interference
-
RNA-Binding Proteins / genetics*
-
RNA-Binding Proteins / metabolism
-
Reverse Transcriptase Polymerase Chain Reaction
-
Transplantation, Heterologous
-
Tumor Burden / genetics
Substances
-
3' Untranslated Regions
-
CPEB3 protein, human
-
MIRN107 microRNA, human
-
MicroRNAs
-
RNA-Binding Proteins
-
EGFR protein, human
-
ErbB Receptors