Prediction of Post-Operative Liver Dysfunction by Serum Markers of Liver Fibrosis in Hepatocellular Carcinoma

PLoS One. 2015 Oct 26;10(10):e0140932. doi: 10.1371/journal.pone.0140932. eCollection 2015.

Abstract

Aim: To investigate the role of biomarkers in predicting postoperative liver dysfunction in patients with hepatocellular carcinoma (HCC).

Methods: A total of 200 patients operated from July 2009 to June 2010 at Zhongshan Hospital, Fudan University for pathologically confirmed HCC were retrospectively analyzed for clinical data, HBD DNA level and serum biochemical markers for liver fibrosis. The patients were followed up to observersation end point. Correlation of the monitored parameters with postoperative liver dysfunction and patient survival was statistically analyzed.

Results: Preoperative hepatitis B virus (HBV) DNA level, serum prealbumin (PA) hyaluronic acid (HA), and laminin (LN) levels correlated with postoperative liver dysfunction, and preoperative LN level also was associated with the patients' survival. A predictive model was generated using these 4 parameters and validated in 89 HCC patients with sensitivity and specificity of 0.625 and 0.912, respectively [corrected]. However, no correlation was identified between postoperative liver function and overall survival.

Conclusion: Liver fibrosis markers could be preoperatively used in predicting postoperative liver dysfunction in HCC patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • Carcinoma, Hepatocellular / blood
  • Carcinoma, Hepatocellular / complications*
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / surgery
  • DNA, Viral / blood
  • Female
  • Hepatitis B virus
  • Humans
  • Hyaluronic Acid / blood
  • Laminin / blood
  • Liver / pathology
  • Liver Cirrhosis / blood
  • Liver Cirrhosis / etiology*
  • Liver Cirrhosis / pathology
  • Liver Function Tests
  • Liver Neoplasms / blood
  • Liver Neoplasms / complications*
  • Liver Neoplasms / pathology
  • Liver Neoplasms / surgery
  • Male
  • Models, Theoretical
  • Prealbumin / analysis
  • Predictive Value of Tests
  • ROC Curve
  • Sensitivity and Specificity

Substances

  • Biomarkers
  • DNA, Viral
  • Laminin
  • Prealbumin
  • Hyaluronic Acid

Grants and funding

This study was jointly supported by the grants from the National Major Science and Technology Project (2012ZX 10002012-004; 2013ZX 10002007). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.