Pharmacokinetics of Bedaquiline in Cerebrospinal Fluid and Serum in Multidrug-Resistant Tuberculous Meningitis

Clin Infect Dis. 2016 Feb 15;62(4):523-4. doi: 10.1093/cid/civ921. Epub 2015 Nov 3.

Authors

Onno W Akkerman¹, Omar F F Odish², Mathieu S Bolhuis³, Wiel C M de Lange¹, Hubertus P H Kremer², Gert-Jan R Luijckx², Tjip S van der Werf⁴, Jan-Willem Alffenaar³

Affiliations

¹ Tuberculosis Centre Beatrixoord Departments of Pulmonary Diseases and Tuberculosis.
² Neurology.
³ Hospital and Clinical Pharmacy.
⁴ Departments of Pulmonary Diseases and Tuberculosis Internal Medicine, University of Groningen, University Medical Center Groningen, The Netherlands.

PMID: 26534926
DOI: 10.1093/cid/civ921

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adult
Antitubercular Agents / administration & dosage
Antitubercular Agents / pharmacokinetics*
Cerebrospinal Fluid / chemistry*
Diarylquinolines / administration & dosage
Diarylquinolines / pharmacokinetics*
Humans
Male
Serum / chemistry*
Tuberculosis, Meningeal / drug therapy*
Tuberculosis, Multidrug-Resistant / drug therapy*

Substances

Antitubercular Agents
Diarylquinolines
bedaquiline