Draft Genome Sequence of a Metronidazole-Resistant Derivative of Gardnerella vaginalis Strain ATCC 14019

Jessica A Schuyler; Eli Mordechai; Martin E Adelson; Scott E Gygax; David W Hilbert

doi:10.1128/genomeA.01345-15

Draft Genome Sequence of a Metronidazole-Resistant Derivative of Gardnerella vaginalis Strain ATCC 14019

Genome Announc. 2015 Nov 12;3(6):e01345-15. doi: 10.1128/genomeA.01345-15.

Authors

Jessica A Schuyler¹, Eli Mordechai¹, Martin E Adelson¹, Scott E Gygax¹, David W Hilbert²

Affiliations

¹ Femeris Women's Health Research Center, Medical Diagnostic Laboratories, a member of Genesis Biotechnology Group, Hamilton, New Jersey, USA.
² Femeris Women's Health Research Center, Medical Diagnostic Laboratories, a member of Genesis Biotechnology Group, Hamilton, New Jersey, USA dhilbert@mdlab.com.

Abstract

We report the genome sequence of a metronidazole-resistant derivative of Gardnerella vaginalis ATCC 14019. This strain was obtained after serial selection to increase the MIC from 4 to ≥500 µg/ml. Two coding changes, in genes encoding a response regulator and an NAD(+) synthetase, arose during selection.