Direct Observation of Early-Stage High-Dose Radiotherapy-Induced Vascular Injury via Basement Membrane-Targeting Nanoparticles

Small. 2015 Dec 22;11(48):6404-10. doi: 10.1002/smll.201501902. Epub 2015 Nov 18.

Authors

Kin Man Au^{1

2}, Sayed Nabeel Hyder^{1

2}, Kyle Wagner^{1

2}, Caihong Shi^{1

2

3}, Young Seok Kim^{1

2

4}, Joseph M Caster^{1

2}, Xi Tian^{1

2}, Yuanzeng Min^{1

2}, Andrew Z Wang^{1

2}

Affiliations

¹ Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
² Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
³ School of Transnational Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang, Liaoning, 110016, China.
⁴ Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, 138-736, South Korea.

Abstract

Collagen IV-targeting peptide-conjugated basement membrane-targeting nanoparticles are successfully engineered to identify early-stage blood vessel injury induced by high-dose radiotherapy.

Keywords: basement membrane-targeting nanoparticles; cancer; cardiovascular disease; medical imaging; radiotherapy.

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Basement Membrane / drug effects
Basement Membrane / metabolism*
Collagen Type IV / pharmacology
Dose-Response Relationship, Radiation
Fluorescence
Lactic Acid / chemistry
Mice, Nude
Nanoparticles / chemistry*
Optical Imaging
Polyethylene Glycols / chemistry
Polyglycolic Acid / chemistry
Polylactic Acid-Polyglycolic Acid Copolymer
Radiation Injuries / diagnosis*
Radiotherapy / adverse effects*
Vascular System Injuries / diagnosis*

Substances

Collagen Type IV
Polylactic Acid-Polyglycolic Acid Copolymer
Polyglycolic Acid
Lactic Acid
Polyethylene Glycols

Grants and funding