Scanning proton beam therapy reduces normal tissue exposure in pelvic radiotherapy for anal cancer

Aman Anand; Martin Bues; William G Rule; Sameer R Keole; Chris J Beltran; Jun Yin; Michael G Haddock; Christopher L Hallemeier; Robert C Miller; Jonathan B Ashman

doi:10.1016/j.radonc.2015.10.027

Scanning proton beam therapy reduces normal tissue exposure in pelvic radiotherapy for anal cancer

Radiother Oncol. 2015 Dec;117(3):505-8. doi: 10.1016/j.radonc.2015.10.027. Epub 2015 Nov 17.

Authors

Affiliations

¹ Department of Radiation Oncology, Mayo Clinic, Phoenix/Scottsdale, United States. Electronic address: anand.aman@mayo.edu.
² Department of Radiation Oncology, Mayo Clinic, Phoenix/Scottsdale, United States.
³ Department of Radiation Oncology, Mayo Clinic, Rochester, United States.
⁴ Cancer Center Statistics, Mayo Clinic, Rochester, United States.
⁵ Department of Radiation Oncology, Mayo Clinic, Jacksonville, United States.

PMID: 26597231
DOI: 10.1016/j.radonc.2015.10.027

Abstract

An inter-comparison planning study between photon beam therapy (IMRT) and scanning proton beam therapy (SPBT) for squamous cell carcinoma of the anus (SCCA) is presented. SPBT plans offer significant reduction (>50%, P=0.008) in doses to small bowel, and bone marrow thereby offering the potential to reduce bowel and hemotoxicities.

Keywords: Anal cancer; Bone marrow sparing; Spot scanning proton planning; Whole pelvis proton therapy.

MeSH terms

Aged
Anus Neoplasms / radiotherapy*
Bone Marrow / radiation effects
Carcinoma, Squamous Cell / radiotherapy*
Female
Humans
Male
Middle Aged
Pelvis / radiation effects*
Proton Therapy*
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Intensity-Modulated