Molecular diagnosis: Implications for ophthalmology

James T Rosenbaum; Cailin H Sibley; Dongseok Choi; Christina A Harrington; Stephen R Planck

doi:10.1016/j.preteyeres.2015.11.001

Molecular diagnosis: Implications for ophthalmology

Prog Retin Eye Res. 2016 Jan:50:25-33. doi: 10.1016/j.preteyeres.2015.11.001. Epub 2015 Dec 1.

Authors

James T Rosenbaum¹, Cailin H Sibley², Dongseok Choi³, Christina A Harrington⁴, Stephen R Planck⁵

Affiliations

¹ Devers Eye Institute, Legacy Health Systems, 1040 NW 22nd Avenue, Portland, OR 97210, USA; Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA; Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA. Electronic address: rosenbaj@ohsu.edu.
² Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA. Electronic address: sibleyc@ohsu.edu.
³ Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA; Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA; OHSU-PSU School of Public Health, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address: choid@ohsu.edu.
⁴ Integrated Genomics Laboratory, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA. Electronic address: harringc@ohsu.edu.
⁵ Devers Eye Institute, Legacy Health Systems, 1040 NW 22nd Avenue, Portland, OR 97210, USA; Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA; Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA. Electronic address: plancks@ohsu.edu.

Abstract

The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labeled precision medicine. Jameson and Longo define precision medicine as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations" (Jameson and Longo, 2015). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.

Keywords: Granulomatosis with polyangiitis; Molecular diagnosis; Nonspecific orbital inflammatory disease; Sarcoidosis; Thyroid eye disease; Transcriptomics.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Biopsy
Diagnosis, Differential
Gene Expression Profiling / methods
Humans
Molecular Diagnostic Techniques / methods*
Ophthalmology / methods
Orbital Diseases / diagnosis*
Precision Medicine / methods

Abstract

Publication types

MeSH terms

Grants and funding