An Isolated Metastasis From Clear Cell Renal Cell Carcinoma to the Uterus: A Case Report and Review of Literature

Int J Gynecol Pathol. 2016 Sep;35(5):419-22. doi: 10.1097/PGP.0000000000000253.

Abstract

Ovaries are a favored site for metastatic tumors arising in the female genital tract. Other organs of the mullerian system, that is, the uterine corpus as well as the fallopian tubes, cervix, and the vagina are less commonly involved by metastases. If there is no clinical history of a known extramullerian primary tumor, suspicion that a uterine mass represents metastatic disease is low. We report the case of a renal clear cell carcinoma presenting as an isolated uterine mass and morphologically mimicking a primary endometrial clear cell adenocarcinoma. A review of the English literature yielded only a recent abstract describing 3 cases of renal clear cell carcinoma metastasizing to the endometrium.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Animals
  • Carcinoma, Renal Cell / diagnosis
  • Carcinoma, Renal Cell / pathology
  • Carcinoma, Renal Cell / secondary*
  • Endometrial Neoplasms / diagnosis
  • Endometrial Neoplasms / pathology
  • Endometrial Neoplasms / secondary*
  • Endometrium / pathology
  • Female
  • Frozen Sections
  • Humans
  • Kidney Neoplasms / diagnosis
  • Kidney Neoplasms / pathology*
  • Middle Aged
  • Uterus / pathology