Preserved Error-Monitoring in Borderline Personality Disorder Patients with and without Non-Suicidal Self-Injury Behaviors

PLoS One. 2015 Dec 4;10(12):e0143994. doi: 10.1371/journal.pone.0143994. eCollection 2015.

Abstract

Background: The presence of non-suicidal self-injury acts in Borderline Personality Disorder (BPD) is very prevalent. These behaviors are a public health concern and have become a poorly understood phenomenon in the community. It has been proposed that the commission of non-suicidal self-injury might be related to a failure in the brain network regulating executive functions. Previous studies have shown that BPD patients present an impairment in their capacity to monitor actions and conflicts associated with the performance of certain actions, which suppose an important aspect of cognitive control.

Method: We used Event Related Potentials to examine the behavioral and electrophysiological indexes associated with the error monitoring in two BPD outpatients groups (17 patients each) differentiated according to the presence or absence of non-suicidal self-injury behaviors. We also examined 17 age- and intelligence- matched healthy control participants.

Results: The three groups did not show significant differences in event-related potentials associated with errors (Error-Related Negativity and Pe) nor in theta power increase following errors.

Conclusions: This is the first study investigating the behavioral and electrophysiological error monitoring indexes in BPD patients characterized by their history of non-suicidal self-injury behaviors. Our results show that error monitoring is preserved in BPD patients and suggest that non-suicidal self-injury acts are not related to a dysfunction in the cognitive control mechanisms.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Borderline Personality Disorder / pathology
  • Borderline Personality Disorder / physiopathology*
  • Borderline Personality Disorder / psychology
  • Brain / pathology
  • Brain / physiopathology*
  • Evoked Potentials*
  • Female
  • Humans
  • Male
  • Nerve Net / pathology
  • Nerve Net / physiopathology*
  • Self-Injurious Behavior / pathology
  • Self-Injurious Behavior / physiopathology*
  • Self-Injurious Behavior / psychology

Grants and funding

This research was funded by the “Fundació La Marató de TV3” (2009-092410; www.tv3.cat/marato), Spanish Ministry of Science (www.idi.mineco.gob.es) to JMP (PSI2012-37472) and ARF (PSI2011-29219) and Catalan Government to ARF (2009 SGR 93; www10.gencat.cat). JMP was supported by the Ramon y Cajal Grant (RYC-2007-01614; www.idi.mineco.gob.es) and AVB by a predoctoral IDIBELL grant (06/IDB-001; www.idibell.cat). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.