The anti-tumoral effect of lenalidomide is increased in vivo by hypoxia-inducible factor (HIF)-1α inhibition in myeloma cells

Haematologica. 2016 Mar;101(3):e107-10. doi: 10.3324/haematol.2015.133736. Epub 2015 Dec 11.

Authors

Paola Storti¹, Denise Toscani¹, Irma Airoldi², Valentina Marchica¹, Sophie Maiga³, Marina Bolzoni¹, Elena Fiorini¹, Nicoletta Campanini⁴, Eugenia Martella⁴, Cristina Mancini⁴, Daniela Guasco¹, Valentina Ferri⁵, Gaetano Donofrio⁶, Franco Aversa¹, Martine Amiot³, Nicola Giuliani⁷

Affiliations

¹ Myeloma Unit, Department of Clinical and Experimental Medicine, University of Parma, Italy.
² Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova, Italy.
³ INSERM, U892, University of Nantes, CNRS, UMR 6299, France.
⁴ Pathologic Anatomy and Histology, "Azienda Ospedaliero-Universitaria" of Parma, Italy.
⁵ Myeloma Unit, Department of Clinical and Experimental Medicine, University of Parma, Italy Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
⁶ Department of Medical-Veterinary Science, University of Parma, Italy.
⁷ Myeloma Unit, Department of Clinical and Experimental Medicine, University of Parma, Italy nicola.giuliani@unipr.it.

No abstract available

Keywords: hypoxia inducible factor (HIF)-1α suppression; in vivo; lenalidomide sensitivity; multiple myeloma.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Caspase 3 / genetics
Caspase 3 / immunology
Cyclin-Dependent Kinase Inhibitor p27 / genetics
Cyclin-Dependent Kinase Inhibitor p27 / immunology
Disease Models, Animal
Gene Expression Regulation, Neoplastic*
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / antagonists & inhibitors
Hypoxia-Inducible Factor 1, alpha Subunit / genetics*
Hypoxia-Inducible Factor 1, alpha Subunit / immunology
Ikaros Transcription Factor / genetics
Ikaros Transcription Factor / immunology
Immunologic Factors / pharmacology*
Interferon Regulatory Factors / genetics
Interferon Regulatory Factors / immunology
Lenalidomide
Mice
Mice, Inbred NOD
Mice, SCID
Mitogen-Activated Protein Kinase 1 / genetics
Mitogen-Activated Protein Kinase 1 / immunology
Mitogen-Activated Protein Kinase 3 / genetics
Mitogen-Activated Protein Kinase 3 / immunology
Multiple Myeloma / genetics
Multiple Myeloma / immunology
Multiple Myeloma / pathology
Multiple Myeloma / therapy*
Plasma Cells / drug effects*
Plasma Cells / immunology
Plasma Cells / pathology
RNA, Small Interfering / genetics
RNA, Small Interfering / metabolism
S-Phase Kinase-Associated Proteins / genetics
S-Phase Kinase-Associated Proteins / immunology
Signal Transduction
Thalidomide / analogs & derivatives*
Thalidomide / pharmacology
Trans-Activators / genetics
Trans-Activators / immunology

Substances

Hif1a protein, mouse
Hypoxia-Inducible Factor 1, alpha Subunit
Ikzf3 protein, mouse
Immunologic Factors
Interferon Regulatory Factors
RNA, Small Interfering
S-Phase Kinase-Associated Proteins
Trans-Activators
Zfpn1a1 protein, mouse
interferon regulatory factor-4
Cyclin-Dependent Kinase Inhibitor p27
Ikaros Transcription Factor
Thalidomide
Mapk1 protein, mouse
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Casp3 protein, mouse
Caspase 3
Lenalidomide