Wearable Second Harmonic Generation Imaging: The Sarcomeric Bridge to the Clinic

Justin C Williams; Paul J Campagnola

doi:10.1016/j.neuron.2015.12.009

Wearable Second Harmonic Generation Imaging: The Sarcomeric Bridge to the Clinic

Neuron. 2015 Dec 16;88(6):1067-1069. doi: 10.1016/j.neuron.2015.12.009.

Authors

Justin C Williams¹, Paul J Campagnola²

Affiliations

¹ Department of Biomedical Engineering, University of Wisconsin-Madison, 1550 Engineering Drive, Madison, WI 53706, USA.
² Department of Biomedical Engineering, University of Wisconsin-Madison, 1550 Engineering Drive, Madison, WI 53706, USA. Electronic address: pcampagnola@wisc.edu.

PMID: 26687213
DOI: 10.1016/j.neuron.2015.12.009

Abstract

Imaging of sarcomere dynamics in vivo in patients has significant clinical importance, as the structure and function is altered in numerous pathologies. In this issue of Neuron, Schnitzer and coworkers (Sanchez et al., 2015) demonstrate this capability through a miniature, wearable Second Harmonic Generation microscope.

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MeSH terms

Animals
Endoscopy / methods*
Female
Humans
Male
Muscle Contraction / physiology*
Recruitment, Neurophysiological / physiology*
Sarcomeres / physiology*