The future of endovascular treatment: Insights from the ESCAPE investigators

Evgenia Klourfeld; Charlotte Zerna; Fahad S Al-Ajlan; Noreen Kamal; Privia Randhawa; Amy Y Yu; Dar Dowlatshahi; John Thornton; David Williams; Christine Holmstedt; Michael Kelly; Donald Frei; Blaise Baxter; Guillermo Linares; Oh Young Bang; Alexandre Y Poppe; Walter Montanera; Jeremy Rempel; Muneer Eesa; Bijoy K Menon; Andrew M Demchuk; Mayank Goyal; Michael D Hill; ESCAPE Trial Investigators

doi:10.1177/1747493015622962

The future of endovascular treatment: Insights from the ESCAPE investigators

Int J Stroke. 2016 Feb;11(2):156-63. doi: 10.1177/1747493015622962.

Authors

Evgenia Klourfeld¹, Charlotte Zerna¹, Fahad S Al-Ajlan¹, Noreen Kamal¹, Privia Randhawa¹, Amy Y Yu¹, Dar Dowlatshahi², John Thornton³, David Williams⁴, Christine Holmstedt⁵, Michael Kelly⁶, Donald Frei⁷, Blaise Baxter⁸, Guillermo Linares⁹, Oh Young Bang¹⁰, Alexandre Y Poppe¹¹, Walter Montanera¹², Jeremy Rempel¹³, Muneer Eesa¹⁴, Bijoy K Menon¹, Andrew M Demchuk¹, Mayank Goyal¹⁴, Michael D Hill¹⁵; ESCAPE Trial Investigators

Affiliations

¹ Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
² Department of Medicine (Neurology), the Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
³ Beaumont Hospital, Dublin, Ireland.
⁴ Department of Geriatric and Stroke Medicine, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland.
⁵ Medical University of South Carolina, Charlston, SC, USA.
⁶ Royal Saskatchewan Hospital, University of Saskatchewan, Saskatoon, SK, Canada.
⁷ Swedish Medical Center, Colorado Neurological Institute, Denver, CO, USA.
⁸ Department of Neurology, Erlanger Hospital, Chattanooga, TN, USA.
⁹ Departments of Neurology, Neurosurgery and Radiology, Temple University, Philadelphia, PA, USA.
¹⁰ Department of Neurology, Samsung Medical Center, Seoul, Korea.
¹¹ Department of Neurosciences, Université de Montréal, Montréal, QC, Canada.
¹² Department of Radiology, University of Toronto, Toronto, ON, Canada.
¹³ Department of Radiology, University of Alberta, Edmonton, AB, Canada.
¹⁴ Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada Department of Radiology, University of Calgary, Calgary, AB, Canada.
¹⁵ Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada Department of Radiology, University of Calgary, Calgary, AB, Canada Department of Medicine, University of Calgary, Calgary, AB, Canada Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada michael.hill@ucalgary.ca.

PMID: 26783306
DOI: 10.1177/1747493015622962

Abstract

The ESCAPE trial demonstrated strong morbidity benefit and mortality reduction for endovascular stroke treatment. Following the release of the main results, the ESCAPE trial investigators convened at a 2-day close-out meeting in March 2015 in Banff, Alberta, Canada. Meeting discussions focused on system implications, procedural characteristics, and future directions. We report the proceedings of the meeting, which provide insights from the trialists into the issues of generalizability, treatment limitations, as well as future directions and opportunities in stroke care optimization.

Keywords: Acute stroke therapy; cerebral infarction; intervention; ischemic stroke; recombinant tissue plasminogen activator; stenting; therapy; thrombolysis.

Publication types

Congress
Research Support, Non-U.S. Gov't

MeSH terms

Endovascular Procedures / methods
Endovascular Procedures / trends*
Forecasting*
Humans
Patient Selection
Stents
Stroke / therapy*
Thrombolytic Therapy
Tissue Plasminogen Activator / therapeutic use

Substances

Tissue Plasminogen Activator