Effect of weekly high-dose vitamin D3 supplementation on serum cholecalciferol concentrations in pregnant women

Michelle C Dimitris; Nandita Perumal; Hayley A Craig-Barnes; Michael Leadley; Abdullah A Mahmud; Abdullah H Baqui; Daniel E Roth

doi:10.1016/j.jsbmb.2016.01.007

Effect of weekly high-dose vitamin D3 supplementation on serum cholecalciferol concentrations in pregnant women

J Steroid Biochem Mol Biol. 2016 Apr:158:76-81. doi: 10.1016/j.jsbmb.2016.01.007. Epub 2016 Jan 16.

Authors

Michelle C Dimitris¹, Nandita Perumal², Hayley A Craig-Barnes³, Michael Leadley³, Abdullah A Mahmud⁴, Abdullah H Baqui⁵, Daniel E Roth⁶

Affiliations

¹ Centre for Global Child Health and Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada.
² Centre for Global Child Health and Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON, Canada.
³ Analytical Facility for Bioactive Molecules, Research Institute, Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada.
⁴ Centre for Child and Adolescent Health, icddr,b, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh.
⁵ Centre for Child and Adolescent Health, icddr,b, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh; International Center for Maternal and Newborn Health, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, USA.
⁶ Centre for Global Child Health and Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada; Department of Paediatrics, University of Toronto and Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada. Electronic address: daniel.roth@sickkids.ca.

PMID: 26784272
DOI: 10.1016/j.jsbmb.2016.01.007

Abstract

Vitamin D status is conventionally defined by the serum concentration of 25-hydroxyvitamin D. However, it has been proposed that the serum cholecalciferol concentration (D3) also determines functional vitamin D sufficiency. The objective of this study was to describe the effect of weekly high-dose vitamin D3 supplementation on inter-dose serum D3 in pregnant women. We conducted a sub-study of a completed randomized double-blind placebo-controlled trial of vitamin D3 (35,000 IU/week) supplementation in late pregnancy (AViDD trial) in Dhaka, Bangladesh. This study included pregnant women enrolled at 26-29 weeks gestation who fully adhered to the prenatal supplement intervention for ≥8 consecutive weeks and for whom serum samples were available for D3 analysis (n=65). Serum D3 was uniformly low at enrolment. Mean D3 increased and was maximal at 1 day after vitamin D dose administration (152.09nmol/L, SD 25.11nmol/L) and remained significantly higher in VitD vs. Pl at 7 days (29.59nmol/L vs. 1.92nmol/L, p=0.007). Daily average of the group mean D3 during the week following dosing was 66.97nmol/L in VitD versus 2.13nmol/L in Pl. In conclusion, serum D3 remained significantly elevated throughout the week following ≥8 consecutive weekly doses of 35,000 IU D3 in pregnant women. However, the clinically significant minimum threshold of serum D3 remains to be established.

Keywords: Bangladesh; Cholecalciferol; Pharmacokinetics; Pregnancy; Vitamin D.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cholecalciferol / administration & dosage
Cholecalciferol / blood*
Cholecalciferol / pharmacokinetics*
Dietary Supplements
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Humans
Pregnancy / blood*
Vitamins / administration & dosage
Vitamins / blood*
Vitamins / pharmacokinetics*
Young Adult

Substances

Vitamins
Cholecalciferol