Polyanionic Macromolecular Prodrugs of Ribavirin: Antiviral Agents with a Broad Spectrum of Activity

Tracey M Hinton; Kaja Zuwala; Celine Deffrasnes; Shawn Todd; Shuning Shi; Glenn A Marsh; Megan Dearnley; Benjamin M Wohl; Martin Tolstrup; Alexander N Zelikin

doi:10.1002/adhm.201500841

Polyanionic Macromolecular Prodrugs of Ribavirin: Antiviral Agents with a Broad Spectrum of Activity

Adv Healthc Mater. 2016 Mar 9;5(5):534-40. doi: 10.1002/adhm.201500841. Epub 2016 Jan 20.

Authors

Affiliations

¹ CSIRO-Health and Biosecurity Flagship, Australian Animal Health Laboratory, Geelong, VIC, 3220, Australia.
² Department of Infectious Diseases, Aarhus University Hospital, 8000, Aarhus C, Denmark.
³ Department of Chemistry and the iNano, Interdisciplinary Nanoscience Centre, Aarhus University, 8000, Aarhus C, Denmark.

PMID: 26789641
DOI: 10.1002/adhm.201500841

Abstract

Macromolecular prodrugs are developed as multiarmed agents against diverse viral pathogens. Lead candidates inhibit infectivity and replication of HIV, Ebola, influenza, measles, RSV, etc-thus being broad-spectrum antiviral agents.

Keywords: antiviral agents; broad-spectrum antiviral agents; macromolecular prodrugs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

A549 Cells
Animals
Antiviral Agents / chemistry
Antiviral Agents / pharmacology*
Chick Embryo
HeLa Cells
Humans
Influenza A Virus, H1N1 Subtype / drug effects
Macromolecular Substances / chemistry*
Polyelectrolytes
Polymers / chemistry*
Prodrugs / chemistry
Prodrugs / pharmacology*
Ribavirin / chemistry
Ribavirin / pharmacology*
Rous sarcoma virus / drug effects

Substances

Antiviral Agents
Macromolecular Substances
Polyelectrolytes
Polymers
Prodrugs
polyanions
Ribavirin