Bacterial cell division: experimental and theoretical approaches to the divisome

Sci Prog. 2015;98(Pt 4):313-45. doi: 10.3184/003685015X14461391862881.

Abstract

Cell division is a key event in the bacterial life cycle. It involves constriction at the midcell, so that one cell can give rise to two daughter cells. This constriction is mediated by a ring composed offibrous multimers of the protein FtsZ. However a host of additional factors is involved in the formation and dynamics of this "Z-ring" and this complicated apparatus is collectively known as the "divisome". We review the literature, with an emphasis on mathematical modelling, and show how such theoretical efforts have helped experimentalists to make sense of the at times bewildering data, and plan further experiments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / metabolism*
  • Bacterial Proteins / ultrastructure
  • Cell Division / physiology*
  • Computer Simulation
  • Cytoskeletal Proteins / chemistry*
  • Cytoskeletal Proteins / metabolism*
  • Cytoskeletal Proteins / ultrastructure
  • Cytoskeleton / physiology
  • Escherichia coli / cytology*
  • Escherichia coli / metabolism*
  • Models, Biological*
  • Models, Chemical
  • Structure-Activity Relationship

Substances

  • Bacterial Proteins
  • Cytoskeletal Proteins
  • FtsZ protein, Bacteria