Perinatal Neuroprotection for Extremely Preterm Infants

Am J Perinatol. 2016 Feb;33(3):290-6. doi: 10.1055/s-0035-1571148. Epub 2016 Jan 22.

Abstract

The preterm brain is vulnerable to injury through multiple mechanisms, from direct cerebral injury through ischemia and hemorrhage, indirect injury through inflammatory processes, and aberrations in growth and development. While prevention of preterm birth is the best neuroprotective strategy, this is not always possible. This article will review various obstetric and neonatal practices that have been shown to confer a neuroprotective effect on the developing brain.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Brain Injuries / prevention & control
  • Female
  • Humans
  • Infant, Extremely Premature / growth & development*
  • Infant, Newborn
  • Magnesium Sulfate / therapeutic use
  • Neuroprotection / drug effects*
  • Parturition
  • Postnatal Care / methods*
  • Practice Guidelines as Topic
  • Pregnancy
  • Premature Birth / prevention & control*
  • Prenatal Care / standards*
  • Randomized Controlled Trials as Topic

Substances

  • Adrenal Cortex Hormones
  • Magnesium Sulfate