Chromatographic NMR Spectroscopy with Hollow Silica Spheres

Tania González-García; Tommaso Margola; Adriano Silvagni; Fabrizio Mancin; Federico Rastrelli

doi:10.1002/anie.201510203

Chromatographic NMR Spectroscopy with Hollow Silica Spheres

Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2733-7. doi: 10.1002/anie.201510203. Epub 2016 Jan 25.

Authors

Tania González-García¹, Tommaso Margola², Adriano Silvagni², Fabrizio Mancin², Federico Rastrelli³

Affiliations

¹ Organic and Inorganic Chemistry Departament, University of Oviedo, c/ Julián Clavería, no. 8, Oviedo, 33006, Spain.
² Department of Chemical Sciences, Università degli Studi di Padova, via Marzolo 1, 35131, Padova, Italy.
³ Department of Chemical Sciences, Università degli Studi di Padova, via Marzolo 1, 35131, Padova, Italy. federico.rastrelli@unipd.it.

PMID: 26809047
DOI: 10.1002/anie.201510203

Abstract

The use of micrometric hollow silica spheres is described as a strategy to reduce magnetic field inhomogeneities in the context of NMR chromatography. When employed as a stationary phase, hollow silica microspheres allow the use of common solution-state NMR instruments to measure the diffusion coefficient perturbation induced by the interaction of the analytes with the silica surface.

Keywords: NMR spectroscopy; analysis of mixtures; chromatography; diffusion; silica.

Publication types

Research Support, Non-U.S. Gov't