Infective endocarditis: Clinical presentation, etiology, and early predictors of in-hospital case fatality

Med Mal Infect. 2016 Feb;46(1):44-8. doi: 10.1016/j.medmal.2015.12.012. Epub 2016 Jan 22.

Abstract

Objective: We aimed to assess the clinical presentation, microbial etiology and outcome of patients presenting with infective endocarditis (IE).

Patients and methods: We conducted a four-year retrospective study including all patients presenting with IE.

Results: We included 121 patients in the study. The median age was 74.8years. Most patients had native valve IE (57%). Staphylococcus aureus accounted for 24.8% of all IE. Surgery was indicated for 70 patients (57.9%) but actually performed in only 55 (44.7%). Factors associated with surgery were younger age (P=0.002) and prosthetic valve IE (P=0.001). Risk factors associated with in-hospital mortality were diabetes mellitus (OR=3.17), chronic renal insufficiency (OR=6.62), and surgical indication (OR=3.49). Mortality of patients who underwent surgery was one sixth of that of patients with surgical indication who did not have the surgery (P<0.001).

Keywords: Endocardite infectieuse; Epidemiology; Infective endocarditis; Épidémiologie.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use
  • Cardiac Surgical Procedures / adverse effects
  • Cardiac Surgical Procedures / statistics & numerical data
  • Comorbidity
  • Diabetes Mellitus / epidemiology
  • Embolism / epidemiology
  • Embolism / etiology
  • Endocarditis / drug therapy
  • Endocarditis / epidemiology*
  • Endocarditis / etiology
  • Endocarditis / surgery
  • Female
  • France
  • Heart Valve Prosthesis
  • Heart Valve Prosthesis Implantation / adverse effects
  • Heart Valve Prosthesis Implantation / statistics & numerical data
  • Hospital Mortality*
  • Humans
  • Kidney Failure, Chronic / epidemiology
  • Male
  • Middle Aged
  • Postoperative Complications / epidemiology
  • Postoperative Complications / etiology
  • Postoperative Complications / therapy
  • Prognosis
  • Prosthesis-Related Infections / drug therapy
  • Prosthesis-Related Infections / epidemiology
  • Prosthesis-Related Infections / surgery
  • Retrospective Studies

Substances

  • Anti-Bacterial Agents