Risk factors predictive of occult cancer detection in patients with unprovoked venous thromboembolism

Ryma Ihaddadene; Daniel J Corsi; Alejandro Lazo-Langner; Sudeep Shivakumar; Ryan Zarychanski; Vicky Tagalakis; Susan Solymoss; Nathalie Routhier; James Douketis; Gregoire Le Gal; Marc Carrier

doi:10.1182/blood-2015-11-682963

Risk factors predictive of occult cancer detection in patients with unprovoked venous thromboembolism

Blood. 2016 Apr 21;127(16):2035-7. doi: 10.1182/blood-2015-11-682963. Epub 2016 Jan 27.

Authors

Affiliations

¹ Department of Medicine, University of Ottawa, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Ottawa, ON, Canada;
² Ottawa Hospital Research Institute, Ottawa, ON, Canada;
³ Department of Medicine, and Department of Epidemiology and Biostatistics, University of Western Ontario, London, ON, Canada;
⁴ Department of Hematology, Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada; Department of Medicine, Dalhousie University, Halifax, NS, Canada;
⁵ Department of Medicine, University of Manitoba, Winnipeg, MB, Canada; Department of Hematology and Medical Oncology, CancerCare Manitoba, Winnipeg, MB, Canada;
⁶ Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital, Montreal, QC, Canada; Center for Clinical Epidemiology, Lady Davis Institute, Montreal, QC, Canada;
⁷ Department of Medicine, McGill University, Montreal, QC, Canada; Division of Hematology, Montreal General Hospital and St. Mary's Hospital, Montreal, QC, Canada;
⁸ Department of Medicine, Université de Montréal, Montreal, QC, Canada; Sacre Coeur Hospital, Montreal, QC, Canada;
⁹ St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada; and.
¹⁰ Department of Medicine, University of Ottawa, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Ottawa, ON, Canada; The Ottawa Hospital, Ottawa, ON, Canada.

Abstract

Risk factors predictive of occult cancer detection in patients with a first unprovoked symptomatic venous thromboembolism (VTE) are unknown. Cox proportional hazard models and multivariate analyses were performed to assess the effect of specific risk factors on occult cancer detection within 1 year of a diagnosis of unprovoked VTE in patients randomized in the Screening for Occult Malignancy in Patients with Idiopathic Venous Thromboembolism (SOME) trial. A total of 33 (3.9%; 95% CI, 2.8%-5.4%) out of the 854 included patients received a new diagnosis of cancer at 1-year follow-up. Age ≥ 60 years (hazard ratio [HR], 3.11; 95% CI, 1.41-6.89; ITALIC! P= .005), previous provoked VTE (HR, 3.20; 95% CI, 1.19-8.62; ITALIC! P= .022), and current smoker status (HR, 2.80; 95% CI, 1.24-6.33; ITALIC! P= .014) were associated with occult cancer detection. Age, prior provoked VTE, and smoking status may be important predictors of occult cancer detection in patients with first unprovoked VTE. This trial was registered atwww.clinicaltrials.govas #NCT00773448.

Publication types

Multicenter Study
Randomized Controlled Trial

MeSH terms

Aged
Aged, 80 and over
Early Detection of Cancer* / methods
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasms, Unknown Primary / complications
Neoplasms, Unknown Primary / diagnosis*
Neoplasms, Unknown Primary / epidemiology*
Risk Factors
Venous Thromboembolism / complications
Venous Thromboembolism / diagnosis
Venous Thromboembolism / epidemiology*

Associated data

ClinicalTrials.gov/NCT00773448