Concordance in Anti-OmpC and Anti-I2 Indicate the Influence of Genetic Predisposition: Results of a European Study of Twins with Crohn's Disease

J Crohns Colitis. 2016 Jun;10(6):695-702. doi: 10.1093/ecco-jcc/jjw021. Epub 2016 Jan 27.

Abstract

Background and aims: An adaptive immunological response to microbial antigens has been observed in Crohn's disease (CD). Intriguingly, this serological response precedes the diagnosis in some patients and has also been observed in healthy relatives. We aimed to determine whether genetic factors are implicated in this response in a CD twin cohort.

Methods: In total, 82 twin pairs (Leuven n = 13, Maastricht n = 8, Örebro n = 61) took part: 81 pairs with CD (concordant monozygotic n = 16, discordant monozygotic n = 22, concordant dizygotic n = 3, discordant dizygotic n = 40) and 1 monozygotic pair with both CD and ulcerative colitis. Serology for Pseudomonas fluorescens-related protein (anti-I2), Escherichia coli outer membrane porin C (anti-OmpC), CBir1flagellin (anti-CBir1) and antibodies to oligomannan (anti-Saccharomyces cerevisiae antibody [ASCA]) was determined by standardized enzyme-linked immunoassay.

Results: All markers were more often present in CD twins than in their healthy twin siblings. Using the intraclass correlation coefficient (ICC), agreements in concentrations of anti-OmpC and anti-I2 were observed in discordant monozygotic but not in discordant dizygotic twin pairs with CD (anti-OmpC, ICC 0.80 and -0.02, respectively) and (anti-I2, ICC 0.56 and 0.05, respectively). In contrast, no agreements were found in anti-CBir, immunoglobulin (Ig) G ASCA and ASCA IgA.

Conclusions: We show that anti-I2 and anti-CBir1 statuses have specificity for CD and confirm previous reported specificities for anti-OmpC and ASCA. Based on quantitative analyses and observed ICCs, genetics seems to predispose to the anti-OmpC and anti-I2 response but less to ASCA and anti-CBir1 responses.

Keywords: Crohn’s disease; genetics; serology.

Publication types

  • Twin Study

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Bacterial / blood*
  • Antibodies, Fungal / blood*
  • Biomarkers / blood
  • Colitis, Ulcerative / blood
  • Colitis, Ulcerative / genetics
  • Colitis, Ulcerative / immunology
  • Colitis, Ulcerative / microbiology
  • Crohn Disease / blood
  • Crohn Disease / genetics*
  • Crohn Disease / immunology
  • Crohn Disease / microbiology
  • Enzyme-Linked Immunosorbent Assay
  • Escherichia coli Proteins / immunology
  • Europe
  • Female
  • Flagellin / blood
  • Genetic Predisposition to Disease*
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • Male
  • Middle Aged
  • Porins / immunology*
  • Pseudomonas fluorescens / immunology
  • Retrospective Studies
  • Saccharomyces cerevisiae Proteins / immunology
  • Superantigens / immunology*
  • Twins, Dizygotic
  • Twins, Monozygotic
  • Young Adult

Substances

  • Antibodies, Bacterial
  • Antibodies, Fungal
  • Biomarkers
  • CBir1 flagellin
  • Escherichia coli Proteins
  • Immunoglobulin A
  • Immunoglobulin G
  • OmpC protein
  • PfiT protein, Pseudomonas fluorescens
  • Porins
  • Saccharomyces cerevisiae Proteins
  • Superantigens
  • Flagellin