Insulin-Like Growth Factor Binding Proteins--an Update

Pediatr Endocrinol Rev. 2015 Dec;13(2):521-30.

Abstract

The insulin-like growth factor (IGF) system is essential for normal growth and development, and its perturbation is implicated in a number of diseases. IGF activity is finely regulated by a family of six high-affinity IGF binding proteins (IGFBPs). 1GFBPs usually inhibit IGF actions but may enhance them under certain conditions. Additionally, IGFBPs bind non-IGF ligands in the extracellular space, cell membrane, cytoplasm and nucleus, thereby modulating cell proliferation, survival and migration in an IGF-independent manner. IGFBP activity is regulated by transcriptional mechanisms as well as by post-translational modifications and proteolysis. Understanding the balance between the various actions of IGFBPs in vivo may lead to novel insights into disease processes and possible IGFBP-based therapeutics.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Physiological Phenomena / physiology
  • Humans
  • Insulin-Like Growth Factor Binding Protein 1 / chemistry
  • Insulin-Like Growth Factor Binding Protein 1 / physiology
  • Insulin-Like Growth Factor Binding Protein 2 / chemistry
  • Insulin-Like Growth Factor Binding Protein 2 / physiology
  • Insulin-Like Growth Factor Binding Protein 3 / chemistry
  • Insulin-Like Growth Factor Binding Protein 3 / physiology
  • Insulin-Like Growth Factor Binding Protein 4 / chemistry
  • Insulin-Like Growth Factor Binding Protein 4 / physiology
  • Insulin-Like Growth Factor Binding Protein 5 / chemistry
  • Insulin-Like Growth Factor Binding Protein 5 / physiology
  • Insulin-Like Growth Factor Binding Protein 6 / chemistry
  • Insulin-Like Growth Factor Binding Protein 6 / physiology
  • Insulin-Like Growth Factor Binding Proteins* / chemistry
  • Insulin-Like Growth Factor Binding Proteins* / physiology
  • Molecular Structure
  • Somatomedins / physiology

Substances

  • Insulin-Like Growth Factor Binding Protein 1
  • Insulin-Like Growth Factor Binding Protein 2
  • Insulin-Like Growth Factor Binding Protein 3
  • Insulin-Like Growth Factor Binding Protein 4
  • Insulin-Like Growth Factor Binding Protein 5
  • Insulin-Like Growth Factor Binding Protein 6
  • Insulin-Like Growth Factor Binding Proteins
  • Somatomedins