Abstract
The insulin-like growth factor (IGF) system is essential for normal growth and development, and its perturbation is implicated in a number of diseases. IGF activity is finely regulated by a family of six high-affinity IGF binding proteins (IGFBPs). 1GFBPs usually inhibit IGF actions but may enhance them under certain conditions. Additionally, IGFBPs bind non-IGF ligands in the extracellular space, cell membrane, cytoplasm and nucleus, thereby modulating cell proliferation, survival and migration in an IGF-independent manner. IGFBP activity is regulated by transcriptional mechanisms as well as by post-translational modifications and proteolysis. Understanding the balance between the various actions of IGFBPs in vivo may lead to novel insights into disease processes and possible IGFBP-based therapeutics.
MeSH terms
-
Animals
-
Cell Physiological Phenomena / physiology
-
Humans
-
Insulin-Like Growth Factor Binding Protein 1 / chemistry
-
Insulin-Like Growth Factor Binding Protein 1 / physiology
-
Insulin-Like Growth Factor Binding Protein 2 / chemistry
-
Insulin-Like Growth Factor Binding Protein 2 / physiology
-
Insulin-Like Growth Factor Binding Protein 3 / chemistry
-
Insulin-Like Growth Factor Binding Protein 3 / physiology
-
Insulin-Like Growth Factor Binding Protein 4 / chemistry
-
Insulin-Like Growth Factor Binding Protein 4 / physiology
-
Insulin-Like Growth Factor Binding Protein 5 / chemistry
-
Insulin-Like Growth Factor Binding Protein 5 / physiology
-
Insulin-Like Growth Factor Binding Protein 6 / chemistry
-
Insulin-Like Growth Factor Binding Protein 6 / physiology
-
Insulin-Like Growth Factor Binding Proteins* / chemistry
-
Insulin-Like Growth Factor Binding Proteins* / physiology
-
Molecular Structure
-
Somatomedins / physiology
Substances
-
Insulin-Like Growth Factor Binding Protein 1
-
Insulin-Like Growth Factor Binding Protein 2
-
Insulin-Like Growth Factor Binding Protein 3
-
Insulin-Like Growth Factor Binding Protein 4
-
Insulin-Like Growth Factor Binding Protein 5
-
Insulin-Like Growth Factor Binding Protein 6
-
Insulin-Like Growth Factor Binding Proteins
-
Somatomedins