Perfluorocarbon-Loaded Hollow Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to Enhance the Radiotherapy of Cancer

Adv Mater. 2016 Apr 13;28(14):2716-23. doi: 10.1002/adma.201504617. Epub 2016 Feb 5.

Abstract

Hollow Bi2 Se3 nanoparticles prepared by a cation exchange method are loaded with perfluorocarbon as an oxygen carrier. With these nanoparticles, a promising concept is demonstrated to enhance radiotherapy by not only using their X-ray-absorbing ability to locally concentrate radiation energy in the tumor, but also employing near-infrared light to trigger burst release of oxygen from the nanoparticles to overcome hypoxia-associated radio-resistance.

Keywords: cation exchange; enhanced radiation therapy; hollow structures; overcome tumor hypoxia; oxygen carries.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bismuth / chemistry*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • DNA Damage / drug effects
  • DNA Damage / radiation effects
  • Fluorocarbons / chemistry*
  • Infrared Rays*
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / toxicity
  • Metal Nanoparticles / ultrastructure
  • Mice
  • Microscopy, Electron, Transmission
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Neoplasms / radiotherapy*
  • Organoselenium Compounds / chemistry*
  • Oxygen / chemistry
  • Oxygen / metabolism*
  • Polyethylene Glycols / chemistry
  • Selenium Compounds
  • Transplantation, Homologous

Substances

  • Fluorocarbons
  • Organoselenium Compounds
  • Selenium Compounds
  • Polyethylene Glycols
  • bismuth selenide
  • Oxygen
  • Bismuth