Abstract
Triazole-linked morpholino ((TL)MO) oligonucleic acids were synthesised using the Cu(I) catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the (TL)MO modification gives higher Tm values than the corresponding (TL)DNA modification.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Catalysis
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Copper / chemistry
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Cycloaddition Reaction
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DNA / chemical synthesis
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DNA / chemistry
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Morpholinos / chemical synthesis
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Morpholinos / chemistry*
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Nucleic Acid Denaturation
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Solid-Phase Synthesis Techniques / methods
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Triazoles / chemical synthesis
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Triazoles / chemistry*
Substances
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Morpholinos
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Triazoles
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Copper
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DNA