Properly dividing with YAP

Sci Signal. 2016 Mar 1;9(417):fs3. doi: 10.1126/scisignal.aaf2527.

Abstract

The Hippo pathway prevents organ overgrowth and maintains tissue architecture by inhibiting the transcriptional coactivator YAP. In this issue of Science Signaling, Bui et al. find a role for YAP during cytokinesis that is independent of its transcriptional activity. This function of YAP may be important for maintaining genomic stability in dividing cells.

Publication types

  • Review
  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism
  • Humans
  • Phosphoproteins / metabolism
  • Protein Serine-Threonine Kinases / metabolism*
  • Signal Transduction*
  • Transcription Factors / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Phosphoproteins
  • Transcription Factors
  • Protein Serine-Threonine Kinases