A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase

Chem Commun (Camb). 2016 Jul 12;52(58):9093-6. doi: 10.1039/c6cc00095a.

Abstract

Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.

MeSH terms

  • Fluorescent Dyes / chemistry*
  • Molecular Imaging*
  • Molecular Structure
  • Superoxide Dismutase-1 / analysis*
  • Superoxide Dismutase-1 / metabolism

Substances

  • Fluorescent Dyes
  • Superoxide Dismutase-1