Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease

Amanda Farage Frade; Laurie Laugier; Ludmila Rodrigues Pinto Ferreira; Monique Andrade Baron; Luiz Alberto Benvenuti; Priscila Camillo Teixeira; Isabela Cunha Navarro; Sandrine Cabantous; Frederico Moraes Ferreira; Darlan da Silva Cândido; Fabio Antônio Gaiotto; Fernando Bacal; Pablo Pomerantzeff; Ronaldo Honorato Barros Santos; Jorge Kalil; Edecio Cunha-Neto; Christophe Chevillard

doi:10.1093/infdis/jiw095

Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease

J Infect Dis. 2016 Jul 1;214(1):161-5. doi: 10.1093/infdis/jiw095. Epub 2016 Mar 6.

Authors

Amanda Farage Frade¹, Laurie Laugier², Ludmila Rodrigues Pinto Ferreira³, Monique Andrade Baron⁴, Luiz Alberto Benvenuti⁵, Priscila Camillo Teixeira⁴, Isabela Cunha Navarro⁴, Sandrine Cabantous², Frederico Moraes Ferreira³, Darlan da Silva Cândido⁴, Fabio Antônio Gaiotto⁵, Fernando Bacal⁶, Pablo Pomerantzeff⁶, Ronaldo Honorato Barros Santos⁵, Jorge Kalil⁷, Edecio Cunha-Neto⁴, Christophe Chevillard²

Affiliations

¹ Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385, France Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology.
² Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385, France.
³ Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology University of Santo Amaro, São Paulo, Brazil.
⁴ Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology.
⁵ Division of Pathology.
⁶ Division of Heart Transplantation, Heart Institute.
⁷ Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385, France Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo.

PMID: 26951817
DOI: 10.1093/infdis/jiw095

Abstract

Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.

Keywords: Chagas disease; MIAT; biomarker; cardiomyopathy; dilated; lncRNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chagas Disease / complications*
Chagas Disease / genetics*
Chagas Disease / physiopathology
Female
Gene Expression Profiling*
Humans
Male
Mice
Myocardial Infarction / etiology*
Myocardial Infarction / genetics*
RNA, Long Noncoding*
Transcription Factors

Substances

RNA, Long Noncoding
Transcription Factors