MR Imaging-Guided Partial Volume Correction of PET Data in PET/MR Imaging

Kjell Erlandsson; John Dickson; Simon Arridge; David Atkinson; Sebastien Ourselin; Brian F Hutton

doi:10.1016/j.cpet.2015.09.002

MR Imaging-Guided Partial Volume Correction of PET Data in PET/MR Imaging

PET Clin. 2016 Apr;11(2):161-77. doi: 10.1016/j.cpet.2015.09.002. Epub 2015 Nov 27.

Authors

Kjell Erlandsson¹, John Dickson², Simon Arridge³, David Atkinson⁴, Sebastien Ourselin⁵, Brian F Hutton⁶

Affiliations

¹ Institute of Nuclear Medicine, University College London, UCLH, Euston Road (T-5), London NW1 2BU, UK. Electronic address: k.erlandsson@ucl.ac.uk.
² Institute of Nuclear Medicine, University College London Hospital, UCLH, Euston Road (T-5), London NW1 2BU, UK.
³ Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK.
⁴ Centre for Medical Imaging, University College London, 250 Euston Road, London NW1 2PG, UK.
⁵ Centre for Medical Imaging Computing, University College London, Gower Street, London WC1E 6BT, UK.
⁶ Institute of Nuclear Medicine, University College London, UCLH, Euston Road (T-5), London NW1 2BU, UK; The Centre for Medical Radiation Physics, University of Wollongong, Northfields Avenue, Wollongong NSW 2522, Australia.

PMID: 26952729
DOI: 10.1016/j.cpet.2015.09.002

Abstract

Partial volume effects are caused by the limited spatial resolution of the PET system. There is increasing evidence that partial volume correction (PVC) is necessary to guarantee quantitative accuracy in PET; however, there is reluctance to apply PVC routinely in clinical practice, partly because of uncertainty regarding the method of choice. To perform accurate PVC, it is necessary to introduce information from high-resolution anatomic images, such as MR imaging. All the methods rely on accurate coregistration between the anatomic image and the PET image. PET/MR imaging offers clear advantages for PVC and can help alleviate the image registration issues.

Keywords: PET/MR imaging; Partial volume correction; Partial volume effects; Quantification.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain Diseases / diagnostic imaging
Cardiovascular Diseases / diagnostic imaging
Coronary Circulation
Heart / diagnostic imaging
Humans
Image Enhancement / methods
Magnetic Resonance Imaging / methods*
Magnetic Resonance Imaging / standards
Multimodal Imaging / methods*
Multimodal Imaging / standards
Neoplasms / diagnostic imaging
Phantoms, Imaging
Positron-Emission Tomography / methods*
Positron-Emission Tomography / standards

Grants and funding

Department of Health/United Kingdom