STAT3 inhibitor has potent antitumor activity in B-lineage acute lymphoblastic leukemia cells overexpressing the high mobility group A1 (HMGA1)-STAT3 pathway

Leuk Lymphoma. 2016 Nov;57(11):2681-4. doi: 10.3109/10428194.2016.1153089. Epub 2016 Mar 8.

Authors

Amy Belton¹, Lingling Xian¹, Tait Huso¹, Michael Koo¹, Li Z Luo¹, James Turkson², Brent D G Page³, Patrick T Gunning³, Guosheng Liu⁴, David L Huso^{4

5}, Linda M S Resar^{1

5}

Affiliations

¹ a Hematology Division, Department of Medicine , Johns Hopkins University School of Medicine , Baltimore , MD , USA ;
² b Cell and Molecular Biology Department , John A. Burns School of Medicine, University of Hawaii , Honolulu , HI , USA ;
³ c Department of Chemistry , University of Toronto , Ontario , Canada ;
⁴ d Department of Molecular and Comparative Pathobiology , Johns Hopkins University School of Medicine , Baltimore , MD , USA ;
⁵ e Department of Oncology, Institute for Cellular Engineering , the Johns Hopkins University School of Medicine , Baltimore , MD , USA.

No abstract available

Publication types

Letter

MeSH terms

Aminosalicylic Acids / pharmacology*
Animals
Antineoplastic Agents / pharmacology*
Cell Lineage / drug effects
Cell Lineage / genetics
Gene Expression Regulation, Leukemic / drug effects
HMGA1a Protein / genetics
HMGA1a Protein / metabolism
Humans
Jurkat Cells
Mice
Mice, Nude
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
Precursor Cells, B-Lymphoid / drug effects*
Precursor Cells, B-Lymphoid / metabolism
Precursor Cells, B-Lymphoid / pathology
STAT3 Transcription Factor / antagonists & inhibitors
STAT3 Transcription Factor / genetics
STAT3 Transcription Factor / metabolism
Signal Transduction / drug effects
Signal Transduction / genetics
Sulfonamides / pharmacology*
Tumor Cells, Cultured
Up-Regulation / drug effects
Up-Regulation / genetics
Xenograft Model Antitumor Assays

Substances

Aminosalicylic Acids
Antineoplastic Agents
BP-1-102
STAT3 Transcription Factor
Sulfonamides
HMGA1a Protein

Grants and funding