Proteosome-hydrophobic 'foot' malaria peptide vaccines for Plasmodium falciparum and P. vivax

G H Lowell; W R Ballou; L F Smith; W D Zollinger; W T Hockmeyer

doi:10.1016/0035-9203(89)90614-7

Proteosome-hydrophobic 'foot' malaria peptide vaccines for Plasmodium falciparum and P. vivax

Trans R Soc Trop Med Hyg. 1989:83 Suppl:101-2. doi: 10.1016/0035-9203(89)90614-7.

Authors

G H Lowell¹, W R Ballou, L F Smith, W D Zollinger, W T Hockmeyer

Affiliation

¹ Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, DC 20307-5100.

PMID: 2696152
DOI: 10.1016/0035-9203(89)90614-7

Abstract

The immunogenicity of synthetic peptides representing the repeating portions of circumsporozoite proteins of Plasmodium sporozoites was greatly increased by complexing them to proteosomes via hydrophobic moieties added to their amino termini. Proteosomes have been used safely in people in the development of meningococcal vaccines and therefore proteosome-peptide vaccines are prime candidates for use against malaria.

MeSH terms

Adjuvants, Immunologic*
Animals
Antibodies, Protozoan / biosynthesis
Antigens, Protozoan / immunology*
Bacterial Outer Membrane Proteins / immunology
Humans
Macromolecular Substances
Malaria / prevention & control*
Oligopeptides / immunology
Plasmodium falciparum / immunology
Plasmodium vivax / immunology
Protozoan Proteins*
Vaccines / immunology*
Vaccines, Synthetic / immunology*

Substances

Adjuvants, Immunologic
Antibodies, Protozoan
Antigens, Protozoan
Bacterial Outer Membrane Proteins
Macromolecular Substances
Oligopeptides
Protozoan Proteins
Vaccines
Vaccines, Synthetic
circumsporozoite protein, Protozoan