Age, not therapy intensity, determines outcomes of adults with acute myeloid leukemia

T Büchner; U O Krug; R Peter Gale; A Heinecke; M C Sauerland; C Haferlach; S Schnittger; T Haferlach; C Müller-Tidow; M Stelljes; R M Mesters; H L Serve; J Braess; K Spiekermann; P Staib; A Grüneisen; A Reichle; L Balleisen; H Eimermacher; A Giagounidis; H Rasche; E Lengfelder; D Görlich; A Faldum; W Köpcke; R Hehlmann; B J Wörmann; W E Berdel; W Hiddemann

doi:10.1038/leu.2016.54

Age, not therapy intensity, determines outcomes of adults with acute myeloid leukemia

Leukemia. 2016 Aug;30(8):1781-4. doi: 10.1038/leu.2016.54. Epub 2016 Mar 11.

Authors

T Büchner¹, U O Krug², R Peter Gale³, A Heinecke⁴, M C Sauerland⁴, C Haferlach⁵, S Schnittger⁵, T Haferlach⁵, C Müller-Tidow¹, M Stelljes¹, R M Mesters¹, H L Serve⁶, J Braess⁷, K Spiekermann⁸, P Staib⁹, A Grüneisen¹⁰, A Reichle¹¹, L Balleisen¹², H Eimermacher¹³, A Giagounidis¹⁴, H Rasche¹⁵, E Lengfelder¹⁶, D Görlich⁴, A Faldum⁴, W Köpcke⁴, R Hehlmann¹⁶, B J Wörmann¹⁷, W E Berdel¹, W Hiddemann⁸

Affiliations

¹ Department of Medicine A, Hematology, Oncology and Pneumology, University of Münster, Münster, Germany.
² Department of Hematology and Oncology, Klinikum Leverkusen; Leverkusen, Germany.
³ Division of Experimental Medicine, Department of Medicine, Haematology Research Centre, Imperial College London, London, UK.
⁴ Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.
⁵ MLL Munich Leukemia Laboratory, Munich, Germany.
⁶ Department of Hematology and Oncology, University of Frankfurt, Germany.
⁷ Department of Hematology and Oncology, Krankenhaus Barmherzige Brüder, Regensburg, Germany.
⁸ Department of Internal Medicine III, University Hospital Munich, Grosshadern, Munich, Germany.
⁹ Department of Hematology and Oncology, St -Antonius Hospital, Eschweiler, Germany.
¹⁰ Department of Hematology and Oncology, Vivantes Clinic Neukölln, Berlin, Germany.
¹¹ Department of Hematology and Oncology, University Regensburg, Regensburg, Germany.
¹² Department of Hematology and Oncology, Evangelisches Krankenhaus, Hamm, Germany.
¹³ Department of Hematology and Oncology, KKH St Marien Hospital, Hagen, Germany.
¹⁴ Marienhospital Düsseldorf, Clinic for Oncology, Hematology and Palliative Care, Düsseldorf, Germany.
¹⁵ Department of Hematology and Oncology, Klinikum Bremen-Mitte, Bremen, Germany.
¹⁶ Department of Hematology and Oncology, University of Heidelberg, Mannheim, Germany.
¹⁷ German Society of Hematology and Oncology, Berlin, Germany.

PMID: 26965440
DOI: 10.1038/leu.2016.54

No abstract available

Publication types

Letter
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Age Factors*
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Female
Humans
Kaplan-Meier Estimate
Leukemia, Myeloid, Acute / drug therapy*
Male
Middle Aged
Prognosis
Risk Factors
Treatment Outcome
Young Adult