KRABs RegulaTE Gene Expression beyond the Embryo

Christopher J Playfoot; Ian R Adams

doi:10.1016/j.devcel.2016.03.006

KRABs RegulaTE Gene Expression beyond the Embryo

Dev Cell. 2016 Mar 21;36(6):591-2. doi: 10.1016/j.devcel.2016.03.006.

Authors

Christopher J Playfoot¹, Ian R Adams²

Affiliations

¹ MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
² MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address: ian.adams@igmm.ed.ac.uk.

PMID: 27003931
DOI: 10.1016/j.devcel.2016.03.006

Abstract

Transposable element (TE) silencing is initiated early in mammalian development and maintained during somatic differentiation. Reporting in this issue of Developmental Cell, Ecco et al. (2016) show that in somatic tissues, TE regulation, and its subsequent effect on host gene transcription, is dynamic rather than locked in a silent state.

Publication types

Comment

MeSH terms

Animals
DNA Transposable Elements / genetics*
Humans
Repressor Proteins / genetics*
Repressor Proteins / metabolism*
Zinc Fingers / genetics*

Substances

DNA Transposable Elements
Repressor Proteins

Grants and funding

MC_PC_U127580973/MRC_/Medical Research Council/United Kingdom