Graphene-based materials for tissue engineering

Su Ryon Shin; Yi-Chen Li; Hae Lin Jang; Parastoo Khoshakhlagh; Mohsen Akbari; Amir Nasajpour; Yu Shrike Zhang; Ali Tamayol; Ali Khademhosseini

doi:10.1016/j.addr.2016.03.007

Graphene-based materials for tissue engineering

Adv Drug Deliv Rev. 2016 Oct 1;105(Pt B):255-274. doi: 10.1016/j.addr.2016.03.007. Epub 2016 Mar 29.

Authors

Su Ryon Shin¹, Yi-Chen Li², Hae Lin Jang³, Parastoo Khoshakhlagh², Mohsen Akbari⁴, Amir Nasajpour³, Yu Shrike Zhang², Ali Tamayol², Ali Khademhosseini⁵

Affiliations

¹ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: SSHIN4@partners.org.
² Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
³ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁴ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Mechanical Engineering, University of Victoria, Victoria, V8P 5C2, Canada.
⁵ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia; College of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University, Hwayang-dong, Kwangjin-gu, Seoul 143-701, Republic of Korea. Electronic address: ALIK@bwh.harvard.edu.

Abstract

Graphene and its chemical derivatives have been a pivotal new class of nanomaterials and a model system for quantum behavior. The material's excellent electrical conductivity, biocompatibility, surface area and thermal properties are of much interest to the scientific community. Two-dimensional graphene materials have been widely used in various biomedical research areas such as bioelectronics, imaging, drug delivery, and tissue engineering. In this review, we will highlight the recent applications of graphene-based materials in tissue engineering and regenerative medicine. In particular, we will discuss the application of graphene-based materials in cardiac, neural, bone, cartilage, skeletal muscle, and skin/adipose tissue engineering. We will also discuss the potential risk factors of graphene-based materials in tissue engineering. In conclusion, we will outline the opportunities in the usage of graphene-based materials for clinical applications.

Keywords: Graphene; Graphene oxide; Graphene-based materials; Regenerative medicine; Tissue engineering.

Published by Elsevier B.V.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Biocompatible Materials
Graphite*
Humans
Regenerative Medicine
Tissue Engineering*

Substances

Biocompatible Materials
Graphite

Abstract

Publication types

MeSH terms

Substances

Grants and funding